Which enzyme is responsible for the conversion of fructose 2,6-bisphosphate to fructose 6-phosphate?

The enzyme responsible for the conversion of fructose 2,6-bisphosphate to fructose 6-phosphate is fructose bisphosphatase-2 (FBPase-2). This enzyme plays a crucial role in the regulation of glucose metabolism, particularly in gluconeogenesis.

Fructose 2,6-bisphosphate is a potent allosteric regulator of the glycolytic enzyme phosphofructokinase-1 (PFK-1) and also has an inverse relationship with fructose bisphosphatase-1 (FBPase-1), which is involved in gluconeogenesis. When fructose 2,6-bisphosphate is present, it promotes glycolysis by activating PFK-1 while inhibiting FBPase-1, thus reducing the conversion of fructose 1,6-bisphosphate back to fructose 6-phosphate. Conversely, the action of FBPase-2 converts fructose 2,6-bisphosphate to fructose 6-phosphate, thereby reducing the levels of fructose 2,6-bisphosphate and promoting gluconeogenesis.

In summary, FBPase-2 is specifically tasked with converting fruct