What molecule is produced alongside Acetyl-CoA during the conversion of α-ketoglutarate?

During the conversion of α-ketoglutarate to Acetyl-CoA in cellular metabolism, one of the key processes involved is the decarboxylation of α-ketoglutarate. This reaction typically occurs during the citric acid cycle (Krebs cycle) and is catalyzed by the enzyme α-ketoglutarate dehydrogenase complex.

In this reaction, α-ketoglutarate loses a carbon atom, which is released in the form of carbon dioxide (CO2). At the same time, electrons are transferred to NAD+, reducing it to NADH, which is also a significant product of this reaction. However, in this specific scenario, CO2 is emphasized as a product released during the conversion process.

Thus, the correct answer focuses on the production of carbon dioxide during the conversion of α-ketoglutarate to Acetyl-CoA, reflecting the decarboxylation that occurs.