What is the purpose of α-oxidation in fatty acid metabolism?

What is the purpose of α-oxidation in fatty acid metabolism?

• A. To produce acetyl-CoA directly from fatty acids.
• B. To oxidize branched fatty acids into propionyl-CoA.
• C. To convert long-chain fatty acids into short-chain fatty acids.
• D. To synthesize ketone bodies from fatty acids.

Answer: (B)

The purpose of α-oxidation in fatty acid metabolism is indeed to oxidize branched fatty acids into propionyl-CoA. This process is particularly important for the metabolism of certain branched-chain fatty acids, such as phytanic acid, that cannot undergo β-oxidation directly due to their structural characteristics. In α-oxidation, the first step involves the removal of the first carbon from the carboxyl end of the fatty acid molecule, which results in the formation of a shorter branched fatty acid chain, ultimately leading to the production of propionyl-CoA. This propionyl-CoA can then enter pathways for gluconeogenesis or can be further metabolized to succinyl-CoA, which can be used in the citric acid cycle. This function is distinct from other oxidation procedures in fatty acid metabolism, such as β-oxidation, which directly cleaves fatty acids into acetyl-CoA units. Therefore, α-oxidation specifically addresses the unique requirements for metabolizing branched-chain fatty acids, making it an essential pathway in lipid metabolism.

The purpose of α-oxidation in fatty acid metabolism is indeed to oxidize branched fatty acids into propionyl-CoA. This process is particularly important for the metabolism of certain branched-chain fatty acids, such as phytanic acid, that cannot undergo β-oxidation directly due to their structural characteristics.

In α-oxidation, the first step involves the removal of the first carbon from the carboxyl end of the fatty acid molecule, which results in the formation of a shorter branched fatty acid chain, ultimately leading to the production of propionyl-CoA. This propionyl-CoA can then enter pathways for gluconeogenesis or can be further metabolized to succinyl-CoA, which can be used in the citric acid cycle.

This function is distinct from other oxidation procedures in fatty acid metabolism, such as β-oxidation, which directly cleaves fatty acids into acetyl-CoA units. Therefore, α-oxidation specifically addresses the unique requirements for metabolizing branched-chain fatty acids, making it an essential pathway in lipid metabolism.