What enzyme catalyzes the conversion of Fructose 1,6-bisphosphate in gluconeogenesis?

The enzyme that catalyzes the conversion of Fructose 1,6-bisphosphate in gluconeogenesis is Fructose 1,6-bisphosphatase (FBPase-1). This enzyme plays a critical role in the gluconeogenesis pathway, which is the synthesis of glucose from non-carbohydrate precursors.

FBPase-1 catalyzes the hydrolysis of Fructose 1,6-bisphosphate to form Fructose 6-phosphate and inorganic phosphate (Pi). This reaction is a key regulatory step in the gluconeogenic pathway, effectively reversing the action of phosphofructokinase-1 (PFK-1), which is involved in glycolysis. The regulation of FBPase-1 is influenced by various metabolites, including AMP and fructose 2,6-bisphosphate, which helps to ensure that gluconeogenesis is active primarily when glucose is needed, such as during fasting or low-carbohydrate intake.

PEP carboxykinase and Hexokinase perform different roles in gluconeogenesis and glycolysis, respectively. PEP carboxykinase catalyzes the conversion of oxaloacetate to phosphoen